Selank Peptide
August 19, 2026
Product Overview Selank is a synthetic peptide analog derived from tuftsin, a naturally occurring tetrapeptide involved in immune system signaling. The compound is supplied strictly
Semax is a synthetic peptide derived from a fragment of adrenocorticotropic hormone (ACTH), studied in laboratory research examining neurotrophic signaling pathways, neurotransmitter regulation, and neuroendocrine communication networks. It is supplied strictly as a research peptide in lyophilized powder form.
The Semax peptide is based on a modified sequence of ACTH(4–10), a region of the ACTH hormone associated with signaling within the central nervous system. Structural modifications were introduced to increase stability in laboratory preparations and to allow researchers to investigate peptide signaling within neural systems.
Because the brain relies on complex signaling molecules to coordinate communication between neurons, peptides such as Semax are frequently studied in brain research exploring neurotrophic factors, neurotransmitter systems, and neuroendocrine regulatory pathways. Nothing on this page describes a use, benefit, or outcome in humans.
| Property | Detail |
| Compound name | Semax |
| Classification | Synthetic heptapeptide, ACTH(4–10) analog |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Amino acid count | 7 |
| Molecular formula | C37H51N9O10S |
| Molecular weight | ~813.9 g/mol |
| Physical form | Lyophilized powder |
| Purity | 99 purity grade (≥99% purity, HPLC-verified); certificate of analysis available |
| Not supplied as | Nasal spray, pre-mixed pen, capsule, or any ready-to-use format |
| Intended use | Laboratory research use only |
These key characteristics describe the material as shipped. They are not use instructions.
Semax was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. The same molecular genetics research program produced Selank, a tuftsin-derived peptide studied in adjacent neuropeptide literature.
A substantial share of the primary literature on this compound originates in Eastern Europe and was published in Russian-language journals. Because much of that Eastern Europe research reaches English-speaking researchers only in translation, secondary summaries often use looser terminology than the source papers a point addressed in the terminology section below.
Semax is a synthetic heptapeptide composed of seven amino acids, with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. The structure originates from the ACTH(4–10) fragment with a C-terminal Pro-Gly-Pro extension that influences peptide stability in experimental models.
Because ACTH-derived peptides interact with signaling pathways involved in neuroendocrine communication, Semax provides a tool for researchers studying neuropeptide signaling mechanisms in vitro and in animal model systems.
ACTH is a peptide hormone produced by the anterior pituitary gland as part of the hypothalamic–pituitary–adrenal (HPA) axis, the regulatory system that coordinates stress signaling and communication between the brain and endocrine glands.
ACTH-derived peptides participate in several biological systems, including:
Fragments derived from ACTH have been examined in research on neural signaling and cognitive regulatory pathways.
The following describes neutral mechanisms reported in the scientific literature. It does not describe an effect of this product in humans.
Neurotrophic factors are signaling molecules that support neuronal communication and cellular signaling within the brain. Experimental studies have examined how Semax relates to pathways associated with brain-derived neurotrophic factor, and BDNF expression is one of the most frequently reported molecular readouts in this literature. Investigators measure BDNF expression in tissue from treated and control groups as a quantitative endpoint, not as a demonstrated benefit.
Beyond BDNF, published work has profiled broader gene expression changes following Semax exposure in cell culture and rodent tissue, including transcripts associated with neurotrophin signaling, vascular signaling, and immune communication. Gene expression profiling gives researchers a molecular-level readout that behavioral measurement alone cannot supply.
Research models examining Semax have explored interactions with neurotransmitter signaling pathways including:
Synaptic plasticity the capacity of synaptic connections to change in strength is a standard measurement domain in neuropeptide research. Electrophysiological and molecular studies have used synaptic plasticity endpoints such as long-term potentiation in tissue preparations to characterize how peptide signaling relates to synaptic function in model systems.
Because Semax originates from an ACTH fragment, researchers have also studied its relationship to neuroendocrine signaling systems within the central nervous system, where neural and hormonal regulatory pathways intersect.
Much of the published work sits within behavioral physiology, where standardized paradigms convert model-organism behavior into quantifiable scores.
Common study designs include:
Each of these is a measurement framework within experimental biology. Any effect reported in such a study is an effect observed within that model, under that protocol, in that species.
A further body of research examines cognitive signaling systems. In this context, cognitive function refers to measurable task performance in a model organism maze acquisition, object recognition, conditioned avoidance retention and cognitive performance is the scored output of those tasks. Cognitive effects, where reported, are the differences in those scores between experimental groups.
Popular and secondary sources frequently discuss this work using consumer-facing language such as cognitive enhancement, mental clarity, or mental performance. Those phrases are not validated endpoints in the primary research and do not describe this product. Any reference to cognitive enhancement, mental clarity, or mental performance in connection with neuropeptides should be read as informal shorthand in non-scientific writing, not as a demonstrated result and not as a representation of what this compound does in a person.
Researchers reviewing sources on this compound will encounter clinical trial reports published in Eastern Europe, including investigational studies in cerebral ischemia and cognitive disorders, along with smaller reports touching areas such as optic nerve disease and rare neurodevelopmental conditions including Rett syndrome.
These points are stated for completeness of the literature record, with the following limits made explicit:
Search results and translated abstracts contain phrasing that carries implications the primary literature does not support, and consumer-format search terms that do not correspond to anything sold here. Because researchers encounter these phrases when reviewing sources, they are defined in context:
No dosing information is provided with this product.
Neuropeptides are small protein molecules that act as signaling messengers within the nervous system. Unlike classical neurotransmitters, they often regulate longer-duration signaling processes across broader neural networks.
These signaling molecules participate in several biological systems, including:
Because neuropeptides participate in these systems, researchers investigate them to understand how brain function is coordinated across complex signaling networks, and questions about brain function at the network level remain a central motivation for this field.
Research involving Semax has spanned several biological systems associated with neuropeptide signaling:
Most of this work has been conducted in cellular and animal models designed to investigate neural signaling mechanisms in a laboratory research setting.
| Semax | Selank | |
| Parent molecule | ACTH(4–10) fragment | Tuftsin (IgG-derived immune peptide) |
| Length | 7 amino acids | 7 amino acids |
| Common research focus | Neurotrophic signaling pathways | Neurotransmitter and neuroimmune signaling |
| Origin | Institute of Molecular Genetics | Institute of Molecular Genetics |
Both are examined in parallel to investigate how structurally distinct neuropeptide signaling molecules relate to brain communication networks.
Selank — A tuftsin-derived peptide studied in experimental models examining neurotransmitter signaling.
DSIP (Delta Sleep Inducing Peptide) — Studied in research examining neuroendocrine signaling associated with sleep regulation.
Melanocortin peptides — Studied in research examining neuroendocrine communication and central nervous system signaling.
All are sold for laboratory and research purposes only.
Answers below address the most frequently asked questions about this compound.
What is Semax? A synthetic heptapeptide analog of the ACTH(4–10) fragment, studied in laboratory research on neurotrophic, neurotransmitter, and neuroendocrine signaling.
Where was it developed? At the Institute of Molecular Genetics in Russia; most primary literature originates in Eastern Europe.
What purity is supplied? 99% purity, verified by HPLC, with a certificate of analysis available.
Do you sell a nasal spray or pre-mixed pen? No. This product is supplied only as lyophilized powder for laboratory research. No spray, pen, or ready-to-use format is offered.
Do you provide dosing or protocols? No. No dosing, administration, or usage guidance is provided under any circumstances.
Can a person use this product? No. It is sold for laboratory and research purposes only, is not for human consumption, and is not approved for human or veterinary use.
Semax is a synthetic peptide derived from an ACTH fragment and studied in experimental models investigating neurotrophic signaling, neurotransmitter regulation, and neuroendocrine communication within the central nervous system. Reported work spans BDNF and gene expression profiling, synaptic plasticity endpoints, and behavioral physiology in murine models.
Because neuropeptides participate in complex neural signaling networks, Semax gives researchers a tool for examining how peptide signaling molecules relate to brain communication pathways and neuroendocrine regulatory systems.
For Research Use Only (RUO). Products are sold strictly for laboratory and research purposes. Not for human use. Semax is not approved for human or veterinary use and is not intended to diagnose, treat, cure, or prevent any disease.
The information provided is for educational purposes only. It is not medical advice and is not a recommendation, instruction, or suggestion for any use in humans. References to published studies describe those studies within their own model systems and are not representations about this product.
Buyer assumes full responsibility for proper handling, storage, and research use, and for compliance with all applicable laws and institutional requirements. By purchasing, the buyer confirms they are a qualified researcher acquiring this material for laboratory research use only.
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